CDKN3

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.^[5][6][7]

CDKN3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FPZ, 1FQ1
Identifiers
Aliases	CDKN3, CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
External IDs	OMIM: 123832; MGI: 1919641; HomoloGene: 3805; GeneCards: CDKN3; OMA:CDKN3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.2 Start 54,396,849 bp[1] End 54,420,218 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 46,997,998 bp[2] End 47,009,126 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis sperm right testis ventricular zone gonad ganglionic eminence testicle buccal mucosa cell bone marrow trabecular bone Top expressed in seminiferous tubule spermatid spermatocyte yolk sac otic vesicle ventricular zone medial ganglionic eminence lumbar spinal ganglion genital tubercle granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatase activity protein serine/threonine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein binding protein tyrosine/serine/threonine phosphatase activity protein tyrosine phosphatase activity Cellular component nucleus perinuclear region of cytoplasm cytoplasm cytosol Biological process cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell population proliferation dephosphorylation peptidyl-tyrosine dephosphorylation protein dephosphorylation G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1033 72391 Ensembl ENSG00000100526 ENSMUSG00000037628 UniProt Q16667 Q810P3 RefSeq (mRNA) NM_001130851 NM_005192 NM_001330173 NM_028222 NM_001360041 RefSeq (protein) NP_001124323 NP_001317102 NP_005183 NP_082498 NP_001346970 Location (UCSC) Chr 14: 54.4 – 54.42 Mb Chr 14: 47 – 47.01 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.^[7]

Interactions

CDKN3 has been shown to interact with Cyclin-dependent kinase 2,^[8][9][10] Cdk1^[5][9] and MS4A3.^[11]