MS4A3

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.^[5][6]

MS4A3
Identifiers
Aliases	MS4A3, CD20L, HTM4, membrane spanning 4-domains A3
External IDs	OMIM: 606498; MGI: 2158468; HomoloGene: 4472; GeneCards: MS4A3; OMA:MS4A3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 60,056,587 bp[1] End 60,071,115 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 11,606,860 bp[2] End 11,618,215 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow bone marrow cells testicle monocyte blood granulocyte spleen right lung placenta appendix Top expressed in tibiofemoral joint granulocyte fetal liver hematopoietic progenitor cell bone marrow lumbar spinal ganglion gastrula right ventricle body of femur embryo olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm perinuclear region of cytoplasm integral component of membrane membrane endomembrane system plasma membrane specific granule membrane Biological process regulation of cell cycle neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 932 170813 Ensembl ENSG00000149516 ENSG00000284903 ENSMUSG00000024681 UniProt Q96HJ5 Q920C4 RefSeq (mRNA) NM_001031666 NM_001031809 NM_006138 NM_133246 RefSeq (protein) NP_001026836 NP_001026979 NP_006129 NP_573509 Location (UCSC) Chr 11: 60.06 – 60.07 Mb Chr 19: 11.61 – 11.62 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.^[6]

Interactions

MS4A3 has been shown to interact with CDKN3.^[7]