CEBPG

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene.^[5][6] This gene has no introns.

CEBPG
Identifiers
Aliases	CEBPG, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
External IDs	OMIM: 138972; MGI: 104982; HomoloGene: 1368; GeneCards: CEBPG; OMA:CEBPG - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.11 Start 33,373,685 bp[1] End 33,382,686 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B2 Start 34,745,847 bp[2] End 34,755,998 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte mucosa of colon mucosa of sigmoid colon muscle of thigh middle temporal gyrus mucosa of transverse colon body of tongue gingival epithelium jejunum jejunal mucosa Top expressed in olfactory epithelium condyle parotid gland zygote conjunctival fornix lacrimal gland secondary oocyte seminal vesicula fossa left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein homodimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding sequence-specific DNA binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Cellular component nucleoplasm nucleus Biological process regulation of transcription, DNA-templated positive regulation of DNA repair positive regulation of DNA-binding transcription factor activity negative regulation of DNA-binding transcription factor activity transcription, DNA-templated enucleate erythrocyte differentiation immune response mRNA metabolic process B cell differentiation positive regulation of DNA binding positive regulation of transcription by RNA polymerase II natural killer cell mediated cytotoxicity transcription by RNA polymerase II liver development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1054 12611 Ensembl ENSG00000153879 ENSMUSG00000056216 UniProt P53567 P53568 RefSeq (mRNA) NM_001806 NM_001252296 NM_009884 RefSeq (protein) NP_001239225 NP_001797 NP_034014 Location (UCSC) Chr 19: 33.37 – 33.38 Mb Chr 7: 34.75 – 34.76 Mb PubMed search [3] [4]
Wikidata
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The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.^[6][7]

C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.^[8]

C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.^[9]