Centaurin, alpha 1

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.^[5][6]

ADAP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3FEH, 3FM8, 3LJU, 3MDB
Identifiers
Aliases	ADAP1, CENTA1, GCS1L, p42IP4, Centaurin, alpha 1, ArfGAP with dual PH domains 1
External IDs	OMIM: 608114; MGI: 2442201; HomoloGene: 55997; GeneCards: ADAP1; OMA:ADAP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 897,900 bp[1] End 955,407 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 139,257,631 bp[2] End 139,311,377 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment hippocampus proper mucosa of transverse colon anterior cingulate cortex prefrontal cortex right frontal lobe primary visual cortex dorsolateral prefrontal cortex Brodmann area 9 temporal lobe Top expressed in primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte jejunum cerebellar cortex piriform cortex pontine nuclei prefrontal cortex primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding GTPase activator activity inositol 1,3,4,5 tetrakisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol bisphosphate binding Cellular component cytoplasm plasma membrane nucleus cytosol Biological process regulation of GTPase activity cell surface receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11033 231821 Ensembl ENSG00000105963 ENSMUSG00000056413 UniProt O75689 n/a RefSeq (mRNA) NM_006869 NM_001284308 NM_001284309 NM_001284310 NM_001284311 NM_172723 RefSeq (protein) NP_001271237 NP_001271238 NP_001271239 NP_001271240 NP_006860 n/a Location (UCSC) Chr 7: 0.9 – 0.96 Mb Chr 5: 139.26 – 139.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Centaurin, alpha 1 has been shown to interact with:

• Casein kinase 1, alpha 1^[7][8]
• Nucleolin,^[9]
• P110α,^[10]
• PRKCI,^[10]
• Protein kinase D1,^[10] and
• Protein kinase Mζ.^[10]