PRKCI

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.^[5][6][7]

PRKCI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8
Identifiers
Aliases	PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota
External IDs	OMIM: 600539; MGI: 99260; HomoloGene: 37667; GeneCards: PRKCI; OMA:PRKCI - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,222,424 bp[1] End 170,305,977 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 14.65 cM Start 31,049,896 bp[2] End 31,107,108 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell pylorus lower lobe of lung corpus epididymis cardia oral cavity renal medulla mucosa of pharynx nipple palpebral conjunctiva Top expressed in molar ciliary body urothelium hair follicle iris conjunctival fornix transitional epithelium of urinary bladder epithelium of lens primitive streak ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein kinase C activity protein domain specific binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding phospholipid binding ATP binding Cellular component cytosol endosome membrane bicellular tight junction microtubule cytoskeleton Golgi membrane plasma membrane apical part of cell Schmidt-Lanterman incisure apical plasma membrane cell leading edge intercellular bridge extracellular exosome nucleus cytoplasm nucleoplasm protein-containing complex Schaffer collateral - CA1 synapse glutamatergic synapse Biological process negative regulation of neuron apoptotic process positive regulation of glucose import establishment of apical/basal cell polarity intracellular signal transduction response to interleukin-1 phosphorylation Golgi vesicle budding actin filament organization protein targeting to membrane negative regulation of glial cell apoptotic process response to peptide hormone negative regulation of apoptotic process secretion protein phosphorylation positive regulation of endothelial cell apoptotic process positive regulation of NF-kappaB transcription factor activity cytoskeleton organization establishment or maintenance of epithelial cell apical/basal polarity bicellular tight junction assembly positive regulation of neuron projection development cellular response to insulin stimulus eye photoreceptor cell development membrane organization positive regulation of glial cell proliferation cell migration vesicle-mediated transport cell-cell junction organization peptidyl-serine phosphorylation positive regulation of protein localization to plasma membrane positive regulation of Notch signaling pathway regulation of postsynaptic membrane neurotransmitter receptor levels Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5584 18759 Ensembl ENSG00000163558 ENSMUSG00000037643 UniProt P41743 Q62074 RefSeq (mRNA) NM_002740 NM_008857 RefSeq (protein) NP_002731 NP_032883 Location (UCSC) Chr 3: 170.22 – 170.31 Mb Chr 3: 31.05 – 31.11 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbol esters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.^[7]

Interactions

PRKCI has been shown to interact with:

• Centaurin, alpha 1,^[8]
• FRS2,^[9]
• Glyceraldehyde 3-phosphate dehydrogenase,^[10]
• PARD3,^[11][12]
• Phosphoinositide-dependent kinase-1,^[13]
• SMG1 (gene),^[14]
• Sequestosome 1,
• KRAS.^[15]
• Vimentin^[16]

^[17]