Cofilin 1

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.

CFL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BEX, 1Q8G, 1Q8X, 3J0S, 5HVK, 5L6W
Identifiers
Aliases	CFL1, CFL, HEL-S-15, cofilin, cofilin 1
External IDs	OMIM: 601442; MGI: 101757; HomoloGene: 99735; GeneCards: CFL1; OMA:CFL1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,823,022 bp[1] End 65,862,026 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,540,483 bp[2] End 5,545,229 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum pons ventral tegmental area inferior ganglion of vagus nerve Brodmann area 46 subthalamic nucleus superior vestibular nucleus lateral nuclear group of thalamus mucosa of colon pylorus Top expressed in mesencephalon dentate gyrus of hippocampal formation granule cell neural tube rhombencephalon granulocyte primary visual cortex olfactory bulb superior frontal gyrus hippocampus proper ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding actin filament binding signaling receptor binding Cellular component cytoplasm vesicle cell projection membrane focal adhesion nuclear matrix plasma membrane intracellular anatomical structure ruffle membrane actin cytoskeleton cytoskeleton lamellipodium membrane extracellular exosome nucleus extracellular matrix extracellular space cell-cell junction cortical actin cytoskeleton cytosol lamellipodium Biological process response to virus negative regulation of apoptotic process positive regulation by host of viral process cytoskeleton organization Rho protein signal transduction regulation of cell morphogenesis regulation of dendritic spine morphogenesis actin cytoskeleton organization actin filament depolymerization mitotic cytokinesis neural crest cell migration neural fold formation protein phosphorylation actin filament organization establishment of cell polarity actin filament fragmentation positive regulation of actin filament depolymerization response to amino acid interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1072 12631 Ensembl ENSG00000172757 ENSMUSG00000056201 UniProt P23528 P18760 RefSeq (mRNA) NM_005507 NM_007687 RefSeq (protein) NP_005498 NP_031713 Location (UCSC) Chr 11: 65.82 – 65.86 Mb Chr 19: 5.54 – 5.55 Mb PubMed search [3] [4]
Wikidata
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Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.^[5]

One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.^[6][7]

Interactions

Cofilin 1 has been shown to interact with HSPH1^[8] and LIMK1.^[9][10]