CHAF1B

Chromatin assembly factor 1 subunit B is a protein that in humans is encoded by the CHAF1B gene.^[5][6][7]

CHAF1B
Identifiers
Aliases	CHAF1B, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7, chromatin assembly factor 1 subunit B
External IDs	OMIM: 601245; MGI: 1314881; HomoloGene: 48346; GeneCards: CHAF1B; OMA:CHAF1B - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.12-q22.13 Start 36,385,392 bp[1] End 36,419,015 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 54.96 cM Start 93,680,789 bp[2] End 93,703,003 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gastrocnemius muscle muscle of thigh ventricular zone ganglionic eminence buccal mucosa cell testicle stromal cell of endometrium gonad skeletal muscle tissue Top expressed in embryo epiblast genital tubercle primitive streak tail of embryo embryo abdominal wall ventricular zone morula yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding histone binding chromatin binding protein binding Cellular component cytoplasm cytosol CAF-1 complex nucleoplasm nucleus protein-containing complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus DNA replication-dependent chromatin assembly DNA replication cell cycle DNA repair nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8208 110749 Ensembl ENSG00000159259 ENSMUSG00000022945 UniProt Q13112 Q9D0N7 RefSeq (mRNA) NM_005441 NM_028083 RefSeq (protein) NP_005432 NP_082359 Location (UCSC) Chr 21: 36.39 – 36.42 Mb Chr 16: 93.68 – 93.7 Mb PubMed search [3] [4]
Wikidata
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Function

Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.^[7]

Interactions

CHAF1B has been shown to interact with:

• ASF1A,^[8]
• ASF1B,^[8][9] and
• BAZ1B.^[10]