ASF1B

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.^[5][6][7]

ASF1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5BNX, 5BO0
Identifiers
Aliases	ASF1B, CIA-II, anti-silencing function 1B histone chaperone
External IDs	OMIM: 609190; MGI: 1914179; HomoloGene: 56797; GeneCards: ASF1B; OMA:ASF1B - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,119,512 bp[1] End 14,136,613 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C2 Start 84,682,136 bp[2] End 84,696,826 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis mucosa of transverse colon gonad testicle ventricular zone blood rectum lymph node bone marrow Top expressed in fetal liver hematopoietic progenitor cell secondary oocyte zygote tibiofemoral joint primary oocyte otic placode thymus somite condyle endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding protein binding Cellular component chromatin nucleus nucleoplasm protein-containing complex Biological process multicellular organism development DNA replication-dependent chromatin assembly nucleosome assembly cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated spermatogenesis chromatin organization blastocyst hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55723 66929 Ensembl ENSG00000105011 ENSG00000288210 ENSMUSG00000005470 UniProt Q9NVP2 Q9DAP7 RefSeq (mRNA) NM_018154 NM_024184 RefSeq (protein) NP_060624 NP_077146 Location (UCSC) Chr 19: 14.12 – 14.14 Mb Chr 8: 84.68 – 84.7 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.^[7]

Interactions

ASF1B has been shown to interact with TLK2,^[6][8] CHAF1B,^[5][8] TLK1^[6][8] and CHAF1A.^[5][8]