CHST7

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.^[5][6]

CHST7
Identifiers
Aliases	CHST7, C6ST-2, GST-5, carbohydrate sulfotransferase 7
External IDs	OMIM: 300375; MGI: 1891767; HomoloGene: 10531; GeneCards: CHST7; OMA:CHST7 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.3 Start 46,573,765 bp[1] End 46,598,496 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.3 Start 19,925,799 bp[2] End 19,963,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua left ovary right ovary right auricle of heart stromal cell of endometrium testicle left ventricle canal of the cervix left coronary artery subcutaneous adipose tissue Top expressed in right kidney primary oocyte proximal tubule primitive streak interventricular septum secondary oocyte zygote endothelial cell of lymphatic vessel human kidney embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity chondroitin 6-sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane trans-Golgi network Biological process sulfur compound metabolic process chondroitin sulfate biosynthetic process N-acetylglucosamine metabolic process polysaccharide metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56548 60322 Ensembl ENSG00000147119 ENSMUSG00000037347 UniProt Q9NS84 Q9EP78 RefSeq (mRNA) NM_019886 NM_021715 RefSeq (protein) NP_063939 NP_068361 Location (UCSC) Chr X: 46.57 – 46.6 Mb Chr X: 19.93 – 19.96 Mb PubMed search [3] [4]
Wikidata
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Function

This gene belongs to the sulfotransferase gene family. Sulfotransferases generate sulfated glycosaminoglycan (GAG) moieties during chondroitin sulfate biosynthesis. They create considerable structural diversity among chondroitin sulfates by transferring sulfate with remarkable specificity for the underlying oligosaccharide substrate. This gene product mainly transfers sulfate to N-acetylgalactosamine. The regulated expression of each member of this gene family may be an important determinant of sulfated GAGs expression and the associated function of chondroitin sulfates as regulators of many biologic processes. This gene is part of a gene cluster on chromosome Xp11.23.^[6]