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Sulfotransferase
Class of enzymes which transfer a sulfo group (–SO3) between molecules From Wikipedia, the free encyclopedia
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In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R−SO−3) from a donor molecule to an acceptor alcohol (R−OH) or amine (R−NH2).[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R−OSO−3):
![{\displaystyle {\mathrm {R} {-}\mathrm {SO} {\vphantom {A}}_{\smash[{t}]{3}}{\vphantom {A}}^{-}}\ +\ {\mathrm {R} {\vphantom {A}}^{\prime }{-}\mathrm {OH} }\quad {\xrightarrow[{\text{ SULT }}]{}}\quad {\mathrm {R} {-}\mathrm {H} }\ +\ {\mathrm {R} {\vphantom {A}}^{\prime }{-}\mathrm {OSO} {\vphantom {A}}_{\smash[{t}]{3}}{\vphantom {A}}^{-}}}](http://wikimedia.org/api/rest_v1/media/math/render/svg/309f6adbd894014d72d03faf7b24c04b81e1f235)
whereas an amine leads to a sulfamate (R−NH−SO−3):
![{\displaystyle {\mathrm {R} {-}\mathrm {SO} {\vphantom {A}}_{\smash[{t}]{3}}{\vphantom {A}}^{-}}\ +\ {\mathrm {R} {\vphantom {A}}^{\prime }{-}\mathrm {NH} {\vphantom {A}}_{\smash[{t}]{2}}}\quad {\xrightarrow[{\text{ SULT }}]{}}\quad {\mathrm {R} {-}\mathrm {H} }\ +\ {\mathrm {R} {\vphantom {A}}^{\prime }{-}\mathrm {NHSO} {\vphantom {A}}_{\smash[{t}]{3}}{\vphantom {A}}^{-}}}](http://wikimedia.org/api/rest_v1/media/math/render/svg/b5606063c04db8ea36fe2dd0674ec64f45c93be9)
Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.[2]
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Examples
The following are examples of sulfotransferases:
- carbohydrate sulfotransferase: CHST1, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHST10, CHST11, CHST12, CHST13, CHST14
- galactose-3-O-sulfotransferase: GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4
- heparan sulfate 2-O-sulfotransferase: HS2ST1
- heparan sulfate 3-O-sulfotransferase: HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST4, HS3ST5, HS3ST6
- heparan sulfate 6-O-sulfotransferase: HS6ST1, HS6ST2, HS6ST3
- N-deacetylase/N-sulfotransferase: NDST1, NDST2, NDST3, NDST4
- tyrosylprotein sulfotransferase: TPST1, TPST2
- uronyl-2-sulfotransferase
- Estrone sulfotransferase
- Chondroitin 4-sulfotransferase
- other: SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1B1, SULT1C2, SULT1C3, SULT1C4, SULT1D1P, SULT1E1, SULT2A1, SULT2B1, SULT4A1, SULT6B1
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See also
- List of EC numbers (EC 2)#EC 2.8.2: Sulfotransferases
- Wikipedia:MeSH D08#MeSH D08.811.913.817 --- sulfur group transferases .28EC 2.8.29
References
External links
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