CLASP1

Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene.^[5]

CLASP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4K92
Identifiers
Aliases	CLASP1, MAST1, cytoplasmic linker associated protein 1
External IDs	OMIM: 605852; MGI: 1923957; HomoloGene: 41024; GeneCards: CLASP1; OMA:CLASP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.2-q14.3 Start 121,337,776 bp[1] End 121,649,476 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 118,389,058 bp[2] End 118,612,678 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon dorsal motor nucleus of vagus nerve spinal ganglia Region I of hippocampus proper postcentral gyrus cerebellar vermis corpus callosum inferior olivary nucleus lateral nuclear group of thalamus entorhinal cortex Top expressed in myocardium of ventricle right ventricle cardiac muscles atrium atrioventricular valve Rostral migratory stream epithelium of lens median eminence pontine nuclei superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinetochore binding dystroglycan binding microtubule binding microtubule plus-end binding protein binding Cellular component cytoplasm cytosol centrosome Golgi apparatus kinetochore microtubule membrane cortical microtubule cytoskeleton focal adhesion spindle centrosomal corona chromosome microtubule plus-end microtubule organizing center cell cortex spindle microtubule cytoplasmic microtubule basal cortex extracellular exosome chromosome, centromeric region cytoskeleton microtubule kinetochore Biological process establishment of epithelial cell polarity vesicle targeting Golgi organization mitotic spindle organization regulation of epithelial to mesenchymal transition regulation of microtubule cytoskeleton organization positive regulation of epithelial cell migration exit from mitosis cell division establishment or maintenance of cell polarity positive regulation of extracellular matrix disassembly positive regulation of basement membrane assembly involved in embryonic body morphogenesis negative regulation of microtubule depolymerization mitotic spindle assembly microtubule anchoring G2/M transition of mitotic cell cycle microtubule bundle formation negative regulation of microtubule polymerization or depolymerization positive regulation of microtubule polymerization regulation of focal adhesion assembly negative regulation of wound healing, spreading of epidermal cells cell cycle positive regulation of exocytosis negative regulation of stress fiber assembly establishment of spindle orientation astral microtubule organization microtubule organizing center organization establishment of mitotic spindle localization regulation of gastrulation microtubule cytoskeleton organization microtubule nucleation sister chromatid cohesion ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23332 76707 Ensembl ENSG00000074054 ENSMUSG00000064302 UniProt Q7Z460 Q80TV8 RefSeq (mRNA) NM_001142273 NM_001142274 NM_001207051 NM_015282 NM_001378003 NM_001378004 NM_001378005 NM_001395891 NM_001081276 NM_001293300 NM_001293301 NM_029709 NM_177548 NM_001359328 NM_001359329 NM_001359330 NM_001359331 NM_001359334 NM_001359335 NM_001359336 NM_001359337 NM_001359338 NM_001359339 NM_001359340 NM_001359341 NM_001359342 NM_001359343 NM_001359345 NM_001359346 NM_001359347 RefSeq (protein) NP_001135745 NP_001135746 NP_001193980 NP_056097 NP_001364932 NP_001364933 NP_001364934 NP_001280229 NP_001280230 NP_083985 NP_001346257 NP_001346258 NP_001346259 NP_001346260 NP_001346263 NP_001346264 NP_001346265 NP_001346266 NP_001346267 NP_001346268 NP_001346269 NP_001346270 NP_001346271 NP_001346272 NP_001346274 NP_001346275 NP_001346276 Location (UCSC) Chr 2: 121.34 – 121.65 Mb Chr 1: 118.39 – 118.61 Mb PubMed search [3] [4]
Wikidata
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Function

CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals^[6] and plants.^[7] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.^[5][8] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.^[9]