CLEC2D

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.^[3]

CLEC2D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4QKG, 4QKH, 4QKI, 4QKJ, 4WCO
Identifiers
Aliases	CLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDs	OMIM: 605659; HomoloGene: 137257; GeneCards: CLEC2D; OMA:CLEC2D - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 9,664,969 bp[1] End 9,699,553 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte Achilles tendon spleen lymph node blood appendix right uterine tube epithelium of colon monocyte bone marrow cells n/a More reference expression data BioGPS n/a
Gene ontology Molecular function transmembrane signaling receptor activity carbohydrate binding protein binding Cellular component plasma membrane membrane integral component of membrane endoplasmic reticulum integral component of plasma membrane cell surface Biological process regulation of immune response cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29121 n/a Ensembl ENSG00000069493 n/a UniProt Q9UHP7 n/a RefSeq (mRNA) NM_001004419 NM_001004420 NM_001197317 NM_001197318 NM_001197319 NM_013269 n/a RefSeq (protein) NP_001004419 NP_001184246 NP_001184247 NP_001184248 NP_037401 n/a Location (UCSC) Chr 12: 9.66 – 9.7 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.^[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.