KLRB1

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.^[5]

KLRB1
Identifiers
Aliases	KLRB1, CD161, CLEC5B, NKR, NKR-P1, NKR-P1A, NKRP1A, hNKR-P1A, killer cell lectin like receptor B1
External IDs	OMIM: 602890; MGI: 107540; HomoloGene: 84369; GeneCards: KLRB1; OMA:KLRB1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 9,594,551 bp[1] End 9,607,916 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 63.06 cM Start 128,586,190 bp[2] End 128,600,496 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte mucosa of ileum jejunal mucosa blood spleen appendix lymph node amniotic fluid bone marrow epithelium of colon Top expressed in morula embryo sciatic nerve blood spleen jejunum blastocyst thymus utricle white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity carbohydrate binding protein binding Cellular component integral component of membrane plasma membrane membrane Biological process cell surface receptor signaling pathway regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3820 17057 Ensembl ENSG00000111796 ENSMUSG00000030361 UniProt Q12918 P27811 RefSeq (mRNA) NM_002258 NM_001159902 NM_010737 RefSeq (protein) NP_002249 NP_001153374 NP_034867 Location (UCSC) Chr 12: 9.59 – 9.61 Mb Chr 6: 128.59 – 128.6 Mb PubMed search [3] [4]
Wikidata
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Function

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.^[5] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Its engagement by NKR-P1 leads to clustering of the latter on the NK cell surface mediating an inhibitory signalling.^[6]