CLSPN

Claspin is a protein that in humans is encoded by the CLSPN gene.^[5][6][7]

CLSPN
Identifiers
Aliases	CLSPN, claspin
External IDs	OMIM: 605434; MGI: 2445153; HomoloGene: 11138; GeneCards: CLSPN; OMA:CLSPN - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 35,720,218 bp[1] End 35,769,978 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 126,450,728 bp[2] End 126,487,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad ganglionic eminence ventricular zone bone marrow cells stromal cell of endometrium pancreatic ductal cell appendix buccal mucosa cell right testis Top expressed in tail of embryo hand zygote secondary oocyte genital tubercle primary oocyte otic vesicle ventricular zone maxillary prominence epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding anaphase-promoting complex binding Cellular component nucleus nucleoplasm Golgi apparatus Biological process DNA replication cell cycle DNA damage checkpoint signaling mitotic DNA replication checkpoint signaling peptidyl-serine phosphorylation activation of protein kinase activity cellular response to DNA damage stimulus DNA repair protein deubiquitination mitotic G2 DNA damage checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63967 269582 Ensembl ENSG00000092853 ENSMUSG00000042489 UniProt Q9HAW4 Q80YR7 RefSeq (mRNA) NM_001190481 NM_022111 NM_001330490 NM_175554 RefSeq (protein) NP_001177410 NP_001317419 NP_071394 NP_780763 NP_001392727 NP_001392728 NP_001392729 NP_001392730 Location (UCSC) Chr 1: 35.72 – 35.77 Mb Chr 4: 126.45 – 126.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.^[7]

Interactions

CLSPN has been shown to interact with:

• BRCA1,^[8]
• CDC45,^[9]
• CHEK1,^[6]
• POLE,^[9]
• RAD17,^[9] and
• USP7.^[10]