CNKSR1

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.^[5][6]

CNKSR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWV
Identifiers
Aliases	CNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDs	OMIM: 603272; MGI: 2670958; HomoloGene: 4604; GeneCards: CNKSR1; OMA:CNKSR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,177,484 bp[1] End 26,189,884 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 133,955,352 bp[2] End 133,965,710 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle right lobe of thyroid gland right uterine tube left lobe of thyroid gland body of pancreas mucosa of transverse colon minor salivary glands olfactory zone of nasal mucosa Skeletal muscle tissue of rectus abdominis Top expressed in muscle of thigh triceps brachii muscle vastus lateralis muscle temporal muscle gastrocnemius muscle knee joint sternocleidomastoid muscle medial head of gastrocnemius muscle digastric muscle tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein binding Cellular component cytoplasm plasma membrane cell cortex membrane cell-cell junction Biological process Ras protein signal transduction Rho protein signal transduction transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10256 194231 Ensembl ENSG00000142675 ENSMUSG00000028841 UniProt Q969H4 A2A9K7 RefSeq (mRNA) NM_001297647 NM_001297648 NM_006314 NM_001081047 RefSeq (protein) NP_001284576 NP_001284577 NP_006305 NP_001074516 Location (UCSC) Chr 1: 26.18 – 26.19 Mb Chr 4: 133.96 – 133.97 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.^[6]

Interactions

CNKSR1 has been shown to interact with RhoD^[7] and RASSF1.^[8]