RhoD

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RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.^[5] It is encoded by the gene RHOD.^[6]

RHOD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2J1L
Identifiers
Aliases	RHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
External IDs	OMIM: 605781; MGI: 108446; HomoloGene: 22409; GeneCards: RHOD; OMA:RHOD - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,056,847 bp[1] End 67,072,017 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 4,475,487 bp[2] End 4,489,460 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right lobe of liver apex of heart skin of leg skin of abdomen gums gingival epithelium left ventricle skin of thigh amniotic fluid Top expressed in saccule otic placode otic vesicle lip esophagus corneal stroma choroid plexus of fourth ventricle right kidney jejunum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase binding GTP binding GTPase activity Cellular component early endosome endosome membrane endosome membrane cytosol plasma membrane intracellular anatomical structure cytoplasm cell cortex cell division site intracellular membrane-bounded organelle Biological process positive regulation of cell adhesion focal adhesion assembly actin filament bundle assembly regulation of actin cytoskeleton reorganization positive regulation of cell migration lamellipodium assembly Rho protein signal transduction regulation of focal adhesion assembly protein targeting regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction actin filament organization regulation of cell shape cell migration regulation of cell migration establishment or maintenance of actin cytoskeleton polarity regulation of actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29984 11854 Ensembl ENSG00000173156 ENSMUSG00000041845 UniProt O00212 P97348 RefSeq (mRNA) NM_014578 NM_001300886 NM_007485 NM_001329989 RefSeq (protein) NP_001287815 NP_055393 NP_001316918 NP_031511 Location (UCSC) Chr 11: 67.06 – 67.07 Mb Chr 19: 4.48 – 4.49 Mb PubMed search [3] [4]
Wikidata
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It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.^[6][7]

Interactions

RhoD has been shown to interact with CNKSR1^[8] and DIAPH2.^[9]