COG3

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.^[5][6]

COG3
Identifiers
Aliases	COG3, SEC34, component of oligomeric golgi complex 3
External IDs	OMIM: 606975; MGI: 2450151; HomoloGene: 5854; GeneCards: COG3; OMA:COG3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.13 Start 45,464,898 bp[1] End 45,536,701 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 75,939,790 bp[2] End 75,991,998 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right lobe of liver Achilles tendon rectum olfactory zone of nasal mucosa monocyte mucosa of ileum granulocyte pancreatic ductal cell left adrenal cortex Top expressed in otolith organ utricle Paneth cell cumulus cell seminal vesicula hand ciliary body medullary collecting duct lacrimal gland iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi membrane cis-Golgi network membrane Golgi apparatus Golgi cisterna membrane Golgi transport complex trans-Golgi network membrane cytosol plasma membrane Biological process protein glycosylation intracellular protein transport protein stabilization intra-Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport protein transport Golgi organization protein localization to organelle retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83548 338337 Ensembl ENSG00000136152 ENSMUSG00000034893 UniProt Q96JB2 Q8CI04 RefSeq (mRNA) NM_001204476 NM_031431 NM_177381 RefSeq (protein) NP_113619 n/a Location (UCSC) Chr 13: 45.46 – 45.54 Mb Chr 14: 75.94 – 75.99 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.^[6]

Interactions

COG3 has been shown to interact with COG2^[7] and COG1.^[7]