COG1

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.^[5][6]

COG1
Identifiers
Aliases	COG1, CDG2G, LDLB, component of oligomeric golgi complex 1
External IDs	OMIM: 606973; MGI: 1333873; HomoloGene: 8411; GeneCards: COG1; OMA:COG1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 73,193,055 bp[1] End 73,208,507 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 113,539,995 bp[2] End 113,557,880 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum apex of heart right frontal lobe anterior pituitary Brodmann area 9 nucleus accumbens prefrontal cortex cingulate gyrus anterior cingulate cortex muscle of thigh Top expressed in external carotid artery internal carotid artery motor neuron substantia nigra islet of Langerhans seminiferous tubule Paneth cell right ventricle paraventricular nucleus of hypothalamus submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi membrane Golgi apparatus membrane trans-Golgi network membrane Golgi transport complex Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9382 16834 Ensembl ENSG00000166685 ENSMUSG00000018661 UniProt Q8WTW3 Q9Z160 RefSeq (mRNA) NM_018714 NM_013581 RefSeq (protein) NP_061184 NP_038609 Location (UCSC) Chr 17: 73.19 – 73.21 Mb Chr 11: 113.54 – 113.56 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex.^[6]

Interactions

COG1 has been shown to interact with COG4^[7] and COG3.^[8]