COPB2

Coatomer subunit beta is a protein that is encoded by the COPB2 gene in humans.^[5][6]

COPB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	COPB2, beta'-COP, coatomer protein complex subunit beta 2, MCPH19, COPI coat complex subunit beta 2
External IDs	OMIM: 606990; MGI: 1354962; HomoloGene: 3499; GeneCards: COPB2; OMA:COPB2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q23 Start 139,353,946 bp[1] End 139,389,736 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 98,445,774 bp[2] End 98,470,435 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland stromal cell of endometrium beta cell oral cavity body of pancreas mucosa of sigmoid colon bronchial epithelial cell smooth muscle tissue Achilles tendon rectum Top expressed in ascending aorta aortic valve lobe of prostate Paneth cell Rostral migratory stream vas deferens fossa seminal vesicula calvaria pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity protein binding Cellular component cytoplasm cytosol Golgi apparatus membrane Golgi membrane COPI-coated vesicle membrane transport vesicle membrane coat COPI vesicle coat cytoplasmic vesicle endoplasmic reticulum membrane Biological process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum toxin transport endoplasmic reticulum to Golgi vesicle-mediated transport protein transport intracellular protein transport intra-Golgi vesicle-mediated transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9276 50797 Ensembl ENSG00000184432 ENSMUSG00000032458 UniProt P35606 O55029 RefSeq (mRNA) NM_004766 NM_015827 RefSeq (protein) NP_004757 NP_056642 Location (UCSC) Chr 3: 139.35 – 139.39 Mb Chr 9: 98.45 – 98.47 Mb PubMed search [3] [4]
Wikidata
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Function

The Golgi coatomer complex (see MIM 601924) constitutes the coat of non-clathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM]^[6]

Interactions

COPB2 has been shown to interact with:

• COPB1,^[7][8]
• PRKCE,^[9] and
• RGS4.^[10]