COPS6

COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.^[5]

COPS6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4QFT, 4R14, 4WSN
Identifiers
Aliases	COPS6, CSN6, MOV34-34KD, COP9 signalosome subunit 6
External IDs	OMIM: 614729; MGI: 1349439; HomoloGene: 4977; GeneCards: COPS6; OMA:COPS6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 100,088,969 bp[1] End 100,092,187 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 138,159,333 bp[2] End 138,162,908 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium apex of heart muscle of thigh right frontal lobe anterior pituitary muscle layer of sigmoid colon body of uterus nucleus accumbens right hemisphere of cerebellum ectocervix Top expressed in medial ganglionic eminence right kidney interventricular septum efferent ductule lens abdominal wall epithelium of lens endothelial cell of lymphatic vessel yolk sac neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm COP9 signalosome nucleus nucleoplasm cytosol Biological process transcription-coupled nucleotide-excision repair viral process nucleotide-excision repair, DNA damage recognition protein deneddylation post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10980 26893 Ensembl ENSG00000168090 ENSMUSG00000019494 UniProt Q7L5N1 O88545 RefSeq (mRNA) NM_006833 NM_012002 RefSeq (protein) NP_006824 NP_036132 Location (UCSC) Chr 7: 100.09 – 100.09 Mb Chr 5: 138.16 – 138.16 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.^[6]

Interactions

COPS6 has been shown to interact with EIF3S6.^[7]