COUP-TFI

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.^[5][6] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

NR2F1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBL
Identifiers
Aliases	NR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1
External IDs	OMIM: 132890; MGI: 1352451; HomoloGene: 21158; GeneCards: NR2F1; OMA:NR2F1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15 Start 93,583,222 bp[1] End 93,594,611 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 C1|13 41.38 cM Start 78,337,092 bp[2] End 78,347,876 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone optic nerve seminal vesicula trigeminal ganglion left uterine tube germinal epithelium ganglionic eminence parietal pleura lower lobe of lung primary visual cortex Top expressed in vestibular membrane of cochlear duct lateral geniculate nucleus anterior amygdaloid area barrel cortex medial dorsal nucleus ventricular zone vas deferens saccule ciliary body subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity steroid hormone receptor activity sequence-specific DNA binding transcription coactivator activity DNA binding nuclear receptor activity zinc ion binding protein binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific retinoic acid-responsive element binding Cellular component nucleus nucleoplasm cytosol Biological process transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated signal transduction steroid hormone mediated signaling pathway intracellular receptor signaling pathway positive regulation of nucleic acid-templated transcription nervous system development negative regulation of neuron projection development positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7025 13865 Ensembl ENSG00000175745 ENSMUSG00000069171 UniProt P10589 Q60632 RefSeq (mRNA) NM_005654 NM_010151 NM_001347538 NM_001347539 RefSeq (protein) NP_005645 NP_001334467 NP_001334468 NP_034281 NP_001390702 NP_001390704 NP_001390706 Location (UCSC) Chr 5: 93.58 – 93.59 Mb Chr 13: 78.34 – 78.35 Mb PubMed search [3] [4]
Wikidata
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Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.^[7][8] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.^[9]

Interactions

COUP-TFI has been shown to interact with:

• BCL11A,^[10]
• BCL11B,^[10]
• COPS2,^[11] and
• ESR1.^[12]

Clinical

Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.^[13]