CRLF2

Cytokine receptor-like factor 2 (also known as TSLP receptor, TSLP-R) is a protein that in humans is encoded by the CRLF2 gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL).^[5][6][7]

Crystal structure of human TSLP (yellow) in complex with TSLP-R (CRLF2) (magenta) and IL-7Ra (blue) (pdb 5j11)

CRLF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NN5, 4NN6, 4NN7
Identifiers
Aliases	CRLF2, CRL2, CRLF2Y, TSLPR, cytokine receptor-like factor 2, cytokine receptor like factor 2
External IDs	OMIM: 300357, 400023; MGI: 1889506; HomoloGene: 49476; GeneCards: CRLF2; OMA:CRLF2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.23;Yp11.32 Start 1,187,549 bp[1] End 1,212,723 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 109,702,575 bp[2] End 109,706,859 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle appendix gallbladder palpebral conjunctiva smooth muscle tissue rectum bone marrow right lung urinary bladder upper lobe of left lung Top expressed in granulocyte stroma of bone marrow mesenteric lymph nodes ankle subcutaneous adipose tissue fossa substantia nigra decidua barrel cortex tunica media of zone of aorta More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine receptor activity cytokine binding Cellular component membrane integral component of membrane extracellular region plasma membrane external side of plasma membrane receptor complex Biological process interleukin-7-mediated signaling pathway positive regulation of cell population proliferation cytokine-mediated signaling pathway positive regulation of mast cell activation positive regulation of receptor signaling pathway via STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64109 57914 Ensembl ENSG00000205755 ENSMUSG00000033467 UniProt Q9HC73 Q8CII9 RefSeq (mRNA) NM_001012288 NM_022148 NM_001164735 NM_016715 NM_001310694 RefSeq (protein) NP_001012288 NP_071431 NP_001158207 NP_001297623 NP_057924 Location (UCSC) Chr X: 1.19 – 1.21 Mb Chr 5: 109.7 – 109.71 Mb PubMed search [3] [4]
Wikidata
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Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[supplied by OMIM]^[7]