CRTC2

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.^[5][6][7]

CRTC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HTM
Identifiers
Aliases	CRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDs	OMIM: 608972; MGI: 1921593; HomoloGene: 18765; GeneCards: CRTC2; OMA:CRTC2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,947,669 bp[1] End 153,958,615 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 90,161,470 bp[2] End 90,171,432 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte left ovary right ovary right hemisphere of cerebellum right lung spleen right lobe of thyroid gland left lobe of thyroid gland canal of the cervix body of uterus Top expressed in neural layer of retina lumbar spinal ganglion tail of embryo genital tubercle granulocyte lip muscle of thigh cerebellar cortex thymus superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function chromatin binding protein binding cAMP response element binding protein binding Cellular component cytoplasm extracellular exosome nucleus nucleoplasm Biological process gluconeogenesis histone H3-K9 acetylation positive regulation of CREB transcription factor activity viral process regulation of transcription, DNA-templated protein homotetramerization toxin transport glucose homeostasis transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200186 74343 Ensembl ENSG00000160741 ENSMUSG00000027936 UniProt Q53ET0 Q3U182 RefSeq (mRNA) NM_181715 NM_028881 NM_001357152 RefSeq (protein) NP_859066 NP_083157 NP_001344081 Location (UCSC) Chr 1: 153.95 – 153.96 Mb Chr 3: 90.16 – 90.17 Mb PubMed search [3] [4]
Wikidata
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Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.^[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).^[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2^[10] and YWHAQ.^[10][11]