CSTF3

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.^[5][6]

CSTF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OND, 2OOE
Identifiers
Aliases	CSTF3, CSTF-77, cleavage stimulation factor subunit 3
External IDs	OMIM: 600367; MGI: 1351825; HomoloGene: 1014; GeneCards: CSTF3; OMA:CSTF3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 33,077,188 bp[1] End 33,162,371 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E2|2 54.84 cM Start 104,420,868 bp[2] End 104,495,774 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary tendon of biceps brachii ganglionic eminence corpus epididymis ventricular zone right hemisphere of cerebellum right uterine tube buccal mucosa cell right testis sperm Top expressed in primitive streak neural layer of retina superior cervical ganglion otic placode abdominal wall atrioventricular junction ganglionic eminence epiblast endocardial cushion ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding RNA binding Cellular component nucleus nucleoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA polyadenylation mRNA cleavage RNA processing mRNA processing mRNA 3'-end processing RNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1479 228410 Ensembl ENSG00000176102 ENSMUSG00000027176 UniProt Q12996 Q99LI7 RefSeq (mRNA) NM_001033505 NM_001033506 NM_001326 NM_001037326 NM_145529 NM_177253 RefSeq (protein) NP_001028677 NP_001028678 NP_001317 NP_001032403 NP_663504 NP_796227 Location (UCSC) Chr 11: 33.08 – 33.16 Mb Chr 2: 104.42 – 104.5 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

Interactions

CSTF3 has been shown to interact with CSTF2.^[7]