CSTF2

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.^[5][6]

CSTF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1P1T, 2J8P
Identifiers
Aliases	CSTF2, CstF-64, cleavage stimulation factor subunit 2
External IDs	OMIM: 300907; MGI: 1343054; HomoloGene: 80171; GeneCards: CSTF2; OMA:CSTF2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 100,820,359 bp[1] End 100,841,520 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E3 Start 132,959,936 bp[2] End 132,987,568 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte oral cavity gonad palpebral conjunctiva mucosa of pharynx testicle ganglionic eminence buccal mucosa cell epithelium of nasopharynx Top expressed in ventromedial nucleus dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus lateral hypothalamus lateral septal nucleus dorsal tegmental nucleus anterior amygdaloid area ventral tegmental area arcuate nucleus subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding protein binding mRNA binding RNA binding Cellular component mRNA cleavage and polyadenylation specificity factor complex cleavage body nucleoplasm nucleus nuclear body Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA 3'-end processing pre-mRNA cleavage required for polyadenylation tRNA splicing, via endonucleolytic cleavage and ligation mRNA polyadenylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1478 108062 Ensembl ENSG00000101811 ENSMUSG00000031256 UniProt P33240 Q8BIQ5 RefSeq (mRNA) NM_001306206 NM_001306209 NM_001325 NM_001290398 NM_001290399 NM_133196 NM_001359053 NM_001359054 RefSeq (protein) NP_001293135 NP_001293138 NP_001316 NP_001293135.1 NP_001277327 NP_001277328 NP_573459 NP_001345982 NP_001345983 Location (UCSC) Chr X: 100.82 – 100.84 Mb Chr X: 132.96 – 132.99 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.^[6]

Interactions

CSTF2 has been shown to interact with CSTF3,^[7] SUB1,^[8] SYMPK,^[7] BARD1^[9][10] and BRCA1.^[9][10]