WD repeat-containing protein 77

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.^[5][6][7]

WDR77
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GQB, 4X60, 4X61, 4X63, 5EMJ, 5EML, 5EMM, 5FA5, 5EMK, 5C9Z
Identifiers
Aliases	WDR77, MEP-50, MEP50, Nbla10071, p44, p44/Mep50, HKMT1069, WD repeat domain 77
External IDs	OMIM: 611734; MGI: 1917715; HomoloGene: 11466; GeneCards: WDR77; OMA:WDR77 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 111,439,890 bp[1] End 111,449,256 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 105,866,685 bp[2] End 105,877,353 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube apex of heart gastrocnemius muscle right adrenal cortex muscle of thigh mucosa of esophagus body of stomach left ventricle left adrenal gland rectum Top expressed in primitive streak epiblast somite tail of embryo abdominal wall endocardial cushion Gonadal ridge embryo embryo mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyl-CpG binding protein binding nuclear receptor coactivator activity protein-arginine N-methyltransferase activity Cellular component cytoplasm cytosol Golgi apparatus methylosome nucleoplasm nucleus Biological process regulation of transcription by RNA polymerase II secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of cell population proliferation negative regulation of cell population proliferation peptidyl-arginine N-methylation positive regulation of nucleic acid-templated transcription spliceosomal snRNP assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79084 70465 Ensembl ENSG00000116455 ENSMUSG00000000561 UniProt Q9BQA1 Q99J09 RefSeq (mRNA) NM_024102 NM_001317062 NM_001317063 NM_001317064 NM_027432 RefSeq (protein) NP_001303991 NP_001303992 NP_001303993 NP_077007 NP_081708 Location (UCSC) Chr 1: 111.44 – 111.45 Mb Chr 3: 105.87 – 105.88 Mb PubMed search [3] [4]
Wikidata
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Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1^[8] and Protein arginine methyltransferase 5.^[5]