CTTNBP2

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.^[5][6]

CTTNBP2
Identifiers
Aliases	CTTNBP2, C7orf8, CORTBP2, Orf4, cortactin binding protein 2
External IDs	OMIM: 609772; MGI: 1353467; HomoloGene: 14125; GeneCards: CTTNBP2; OMA:CTTNBP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.31 Start 117,710,651 bp[1] End 117,874,139 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A2 Start 18,366,477 bp[2] End 18,514,842 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum ganglionic eminence subthalamic nucleus inferior ganglion of vagus nerve pars reticulata lateral nuclear group of thalamus primary visual cortex endothelial cell external globus pallidus C1 segment Top expressed in lateral septal nucleus subiculum lateral geniculate nucleus piriform cortex medial geniculate nucleus superior cervical ganglion medial dorsal nucleus olfactory tubercle visual cortex anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding Cellular component cytoplasm dendritic spine cell projection cell cortex synaptic vesicle postsynaptic actin cytoskeleton glutamatergic synapse Biological process brain development regulation of synapse organization regulation of modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83992 30785 Ensembl ENSG00000077063 ENSMUSG00000000416 UniProt Q8WZ74 B9EJA2 RefSeq (mRNA) NM_033427 NM_001363349 NM_001363350 NM_001363351 NM_080285 RefSeq (protein) NP_219499 NP_001350278 NP_001350279 NP_001350280 NP_525024 Location (UCSC) Chr 7: 117.71 – 117.87 Mb Chr 6: 18.37 – 18.51 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.^[6]

Interactions

CTTNBP2 has been shown to interact with:

• MOBKL3,^[7]
• PPP2CA,^[7]
• RP6-213H19.1,^[7]
• STRN3,^[7] and
• STRN.^[7]