CUL7

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.^[5][6][7]

CUL7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JNG
Identifiers
Aliases	CUL7, 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDs	OMIM: 609577; MGI: 1913765; HomoloGene: 56683; GeneCards: CUL7; OMA:CUL7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,037,617 bp[1] End 43,053,943 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,961,263 bp[2] End 46,975,290 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium pituitary gland anterior pituitary right uterine tube right adrenal gland right adrenal cortex right lobe of thyroid gland ventricular zone right hemisphere of cerebellum canal of the cervix Top expressed in saccule yolk sac otic vesicle otic placode umbilical cord internal carotid artery external carotid artery human fetus efferent ductule molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol centrosome Golgi apparatus microtubule organizing center Cul7-RING ubiquitin ligase complex perinuclear region of cytoplasm anaphase-promoting complex 3M complex cytoskeleton Biological process Golgi organization ubiquitin-dependent protein catabolic process placenta development mitotic cytokinesis proteolysis vasculogenesis IRE1-mediated unfolded protein response positive regulation of dendrite morphogenesis protein ubiquitination epithelial to mesenchymal transition viral process microtubule cytoskeleton organization regulation of mitotic nuclear division post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9820 66515 Ensembl ENSG00000044090 ENSMUSG00000038545 UniProt Q14999 Q8VE73 RefSeq (mRNA) NM_001168370 NM_014780 NM_001374872 NM_001374873 NM_001374874 NM_025611 RefSeq (protein) NP_001161842 NP_055595 NP_001361801 NP_001361802 NP_001361803 NP_079887 Location (UCSC) Chr 6: 43.04 – 43.05 Mb Chr 17: 46.96 – 46.98 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.^[5]