RBX1

RING-box protein 1 is a protein that in humans is encoded by the RBX1 gene.^[4][5]

RBX1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1LDJ, 1LDK, 1U6G, 2HYE, 2LGV, 3DPL, 3DQV, 3RTR, 4F52, 4P5O
Identifiers
Aliases	RBX1, BA554C12.1, RNF75, ROC1, ring-box 1
External IDs	OMIM: 603814; MGI: 3710517; HomoloGene: 6872; GeneCards: RBX1; OMA:RBX1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 40,951,347 bp[1] End 40,973,309 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber trabecular bone Skeletal muscle tissue of rectus abdominis right ventricle monocyte palpebral conjunctiva beta cell C1 segment olfactory bulb oral cavity n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cullin family protein binding ubiquitin protein ligase activity zinc ion binding metal ion binding ubiquitin-ubiquitin ligase activity protein binding ubiquitin protein ligase binding ubiquitin-protein transferase activity NEDD8 transferase activity transcription factor binding transferase activity protein-containing complex binding Cellular component cytoplasm cullin-RING ubiquitin ligase complex cytosol SCF ubiquitin ligase complex VCB complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul5-RING ubiquitin ligase complex Cul7-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex Cul4B-RING E3 ubiquitin ligase complex nucleus nucleoplasm nuclear SCF ubiquitin ligase complex Cul4-RING E3 ubiquitin ligase complex Biological process nucleotide-excision repair, DNA damage recognition protein monoubiquitination MAPK cascade cellular response to DNA damage stimulus protein neddylation global genome nucleotide-excision repair protein catabolic process regulation of transcription from RNA polymerase II promoter in response to hypoxia transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision negative regulation of canonical Wnt signaling pathway nucleotide-excision repair, preincision complex stabilization DNA repair viral process protein polyubiquitination nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion Wnt signaling pathway SCF complex assembly negative regulation of G2/M transition of mitotic cell cycle post-translational protein modification positive regulation of proteasomal ubiquitin-dependent protein catabolic process interleukin-1-mediated signaling pathway protein ubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 3'-to lesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9978 100043674 Ensembl ENSG00000100387 n/a UniProt P62877 n/a RefSeq (mRNA) NM_014248 XM_006525232 XM_006536722 XM_006537452 RefSeq (protein) NP_055063 n/a Location (UCSC) Chr 22: 40.95 – 40.97 Mb n/a PubMed search [2] [3]
Wikidata
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Function

This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.^[6]

Interactions

RBX1 has been shown to interact with:

• CAND1,^[7][8]
• CUL1,^{[5][9][7][8][10][11]}
• CUL2,^[5][9]
• CUL4A,^[5][9][12]
• CUL5^[5][13]
• CUL7,^[9]
• DCUN1D1,^[8] and
• P70-S6 Kinase 1.^[14]