CXXC1

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene.^[5][6][7]

CXXC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QMB, 3QMC, 3QMD, 3QMG, 3QMH, 3QMI
Identifiers
Aliases	CXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP, CXXC finger protein 1
External IDs	OMIM: 609150; MGI: 1921572; HomoloGene: 32221; GeneCards: CXXC1; OMA:CXXC1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 50,282,343 bp[1] End 50,287,839 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E2 Start 74,349,195 bp[2] End 74,354,567 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum body of pancreas right uterine tube pancreatic ductal cell granulocyte right lobe of thyroid gland skin of leg sural nerve skin of abdomen left lobe of thyroid gland Top expressed in Ileal epithelium tail of embryo genital tubercle neural layer of retina choroid plexus of fourth ventricle lactiferous gland entorhinal cortex perirhinal cortex secondary oocyte otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding protein binding cis-regulatory region sequence-specific DNA binding histone methyltransferase activity (H3-K4 specific) metal ion binding unmethylated CpG binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear matrix nuclear speck nucleus nucleoplasm histone methyltransferase complex cytosol Set1C/COMPASS complex Biological process positive regulation of transcription, DNA-templated IRE1-mediated unfolded protein response histone H3-K4 methylation regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30827 74322 Ensembl ENSG00000154832 ENSMUSG00000024560 UniProt Q9P0U4 Q9CWW7 RefSeq (mRNA) NM_001101654 NM_014593 NM_028868 NM_001378844 RefSeq (protein) NP_001095124 NP_055408 NP_083144 NP_001365773 Location (UCSC) Chr 18: 50.28 – 50.29 Mb Chr 18: 74.35 – 74.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression.^[6]

See also

• PHD finger
• CXXC5