CYP2W1

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.^[5]

CYP2W1
Identifiers
Aliases	CYP2W1, cytochrome P450 family 2 subfamily W member 1
External IDs	OMIM: 615967; MGI: 3616076; HomoloGene: 69239; GeneCards: CYP2W1; OMA:CYP2W1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 983,181 bp[1] End 989,640 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 139,338,372 bp[2] End 139,342,788 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell right adrenal cortex left adrenal cortex vena cava skin of abdomen skin of leg dorsal motor nucleus of vagus nerve internal globus pallidus sural nerve trabecular bone Top expressed in lip embryo zone of skin esophagus genital tubercle ileum colon stomach jejunum limb More reference expression data BioGPS n/a
Gene ontology Molecular function iron ion binding oxidoreductase activity heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen metal ion binding monooxygenase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Cellular component cell surface plasma membrane endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum membrane cytoplasm intracellular membrane-bounded organelle Biological process xenobiotic metabolic process epoxygenase P450 pathway organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54905 545817 Ensembl ENSG00000073067 ENSMUSG00000029541 UniProt Q8TAV3 E9Q816 RefSeq (mRNA) NM_017781 NM_001160265 RefSeq (protein) NP_060251 NP_001153737 Location (UCSC) Chr 7: 0.98 – 0.99 Mb Chr 5: 139.34 – 139.34 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.^[6] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.