Caspase 10

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.^[3]

CASP10
Identifiers
Aliases	CASP10, ALPS2, FLICE2, MCH4, Caspase 10, FLICE-2
External IDs	OMIM: 601762; HomoloGene: 50038; GeneCards: CASP10; OMA:CASP10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.1 Start 201,182,872 bp[1] End 201,229,428 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon granulocyte monocyte rectum buccal mucosa cell spleen bone marrow cells blood Achilles tendon upper lobe of left lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function death effector domain binding peptidase activity cysteine-type peptidase activity protein binding hydrolase activity ubiquitin protein ligase binding cysteine-type endopeptidase activity involved in execution phase of apoptosis cysteine-type endopeptidase activity cysteine-type endopeptidase activity involved in apoptotic signaling pathway cysteine-type endopeptidase activity involved in apoptotic process Cellular component ripoptosome cytosol CD95 death-inducing signaling complex cytoplasm Biological process positive regulation of I-kappaB kinase/NF-kappaB signaling apoptotic signaling pathway cell surface receptor signaling pathway proteolysis apoptotic process regulation of apoptotic process execution phase of apoptosis activation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 843 n/a Ensembl ENSG00000003400 n/a UniProt Q92851 n/a RefSeq (mRNA) NM_001206524 NM_001206542 NM_001230 NM_001306083 NM_032974 NM_032976 NM_032977 n/a RefSeq (protein) NP_001193453 NP_001193471 NP_001221 NP_001293012 NP_116756 NP_116758 NP_116759 n/a Location (UCSC) Chr 2: 201.18 – 201.23 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.

That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[4]

Interactions

Caspase 10 has been shown to interact with FADD,^[5][6][7] CFLAR,^[6][8][9] Caspase 8,^[10][11][12] Fas receptor,^[10][5][13] RYBP,^[14] TNFRSF1A^[10][5] and TNFRSF10B.^[10][13]

See also

• The Proteolysis Map