RYBP

RING1 and YY1-binding protein is a protein that in humans is encoded by the RYBP gene.^[4][5]

RYBP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3IXS
Identifiers
Aliases	RYBP, AAP1, DEDAF, YEAF1, APAP-1, RING1 and YY1 binding protein
External IDs	OMIM: 607535; MGI: 3648043; HomoloGene: 8159; GeneCards: RYBP; OMA:RYBP - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p13 Start 72,371,825 bp[1] End 72,446,621 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung cartilage tissue endothelial cell trabecular bone urethra Region I of hippocampus proper middle frontal gyrus optic nerve placenta inferior ganglion of vagus nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding transcription corepressor activity metal ion binding Cellular component cytoplasm PcG protein complex nucleus nucleoplasm Biological process multicellular organism development histone H2A monoubiquitination regulation of transcription, DNA-templated transcription, DNA-templated apoptotic process negative regulation of transcription by RNA polymerase II negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of apoptotic process positive regulation of transcription, DNA-templated negative regulation of G0 to G1 transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23429 628746 Ensembl ENSG00000281766 ENSG00000163602 n/a UniProt Q8N488 n/a RefSeq (mRNA) NM_012234 XM_036158262 RefSeq (protein) NP_036366 n/a Location (UCSC) Chr 3: 72.37 – 72.45 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RYBP has been shown to interact with:

• Abl gene,^[6]
• CBX2,^[4]
• Caspase 10,^[7]
• E2F2,^[8]
• E2F3,^[8]
• Mdm2,^[9]
• RING1,^[4][10] and
• YY1.^[4]