Cirazoline

Cirazoline is a full agonist at the α_1A adrenergic receptor, a partial agonist at both the α_1B and α_1D adrenergic receptors,^[1] and a nonselective antagonist to the α₂ adrenergic receptor.^[2] It is believed that this combination of properties could make cirazoline an effective vasoconstricting agent.^[2]

Cirazoline

Names
Preferred IUPAC name 2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
Identifiers
CAS Number	59939-16-1 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL13852 Y
ChemSpider	2663 Y
IUPHAR/BPS	515
MeSH	Cirazoline
PubChem CID	2765
UNII	QK318GVY3Y Y
CompTox Dashboard (EPA)	DTXSID4045131
InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15) Y Key: YAORIDZYZDUZCM-UHFFFAOYSA-N Y InChI=1/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15) Key: YAORIDZYZDUZCM-UHFFFAOYAV
SMILES O(c1c(cccc1)C2CC2)CC/3=N/CCN\3
Properties
Chemical formula	C13H16N2O
Molar mass	216.284 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Cirazoline has also been shown to decrease food intake in rats, purportedly through activation of α₁ adrenoceptors in the paraventricular nucleus in the hypothalamus of the brain.^[3] Administration of cirazoline also seemed to present impairment in the spatial memory of monkeys through the activation of the same receptors that showed decreased food intake in rats.^[4][5] However, in preliminary studies, through stimulation of α₂ adrenoceptors, working memory is comparatively improved.^[4]