Cyclin-dependent kinase 10

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.^[5][6][7]

CDK10
Identifiers
Aliases	CDK10, PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
External IDs	OMIM: 603464; MGI: 2448549; HomoloGene: 55769; GeneCards: CDK10; OMA:CDK10 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.3 Start 89,680,737 bp[1] End 89,696,354 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E1 Start 123,951,581 bp[2] End 123,958,989 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland left lobe of thyroid gland anterior pituitary body of pancreas right lobe of liver granulocyte mucosa of transverse colon apex of heart right hemisphere of cerebellum Top expressed in otic vesicle superior frontal gyrus neural layer of retina primary visual cortex dentate gyrus of hippocampal formation granule cell spermatocyte otolith organ utricle hand lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cyclin-dependent protein kinase activity protein binding ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity protein serine/threonine kinase activity Cellular component mediator complex ciliary basal body cytoplasm cytoskeleton cell projection nucleus Biological process traversing start control point of mitotic cell cycle phosphorylation positive regulation of MAPK cascade negative regulation of cell population proliferation protein phosphorylation peptidyl-threonine phosphorylation regulation of actin cytoskeleton organization negative regulation of cilium assembly cell projection organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8558 234854 Ensembl ENSG00000185324 ENSMUSG00000033862 UniProt Q15131 Q3UMM4 RefSeq (mRNA) NM_001098533 NM_001160367 NM_003674 NM_052987 NM_052988 NM_194444 NM_194446 RefSeq (protein) NP_001092003 NP_001153839 NP_443713 NP_443714 NP_919426 NP_919428 Location (UCSC) Chr 16: 89.68 – 89.7 Mb Chr 8: 123.95 – 123.96 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.^[7]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2.^[8]