ETS2

For the video game, see Euro Truck Simulator 2.

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene.^[5][6] The protein encoded by this gene belongs to the ETS family of transcription factors.^[5] It has been found to play a key role in the development of inflammatory bowel disease.^[7][8]

ETS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BQA, 4MHV
Identifiers
Aliases	ETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor
External IDs	OMIM: 164740; MGI: 95456; HomoloGene: 3838; GeneCards: ETS2; OMA:ETS2 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.2 Start 38,805,183 bp[1] End 38,824,955 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 56.64 cM Start 95,502,942 bp[2] End 95,522,095 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen mucosa of urinary bladder skin of leg gastric mucosa rectum spleen upper lobe of left lung ectocervix olfactory zone of nasal mucosa right lung Top expressed in left lung lobe tail of embryo thymus Paneth cell granulocyte skin of external ear right lung skin of back conjunctival fornix right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding glucocorticoid receptor binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component plasma membrane nucleoplasm nucleus cytosol Biological process skeletal system development cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated ectodermal cell fate commitment mesoderm development primitive streak formation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2114 23872 Ensembl ENSG00000157557 ENSMUSG00000022895 UniProt P15036 P15037 RefSeq (mRNA) NM_001256295 NM_005239 NM_011809 RefSeq (protein) NP_001243224 NP_005230 NP_035939 Location (UCSC) Chr 21: 38.81 – 38.82 Mb Chr 16: 95.5 – 95.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ETS2 has been shown to interact with:

• C-jun,^[9]
• Cyclin-dependent kinase 10,^[10]
• ERG,^[9]
• myb,^[11] and
• ZMYND11.^[12]

Clinical significance

ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22.^[13]