HEXIM1

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.^[5][6][7]

HEXIM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GD7, 3S9G
Identifiers
Aliases	HEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1
External IDs	OMIM: 607328; MGI: 2385923; HomoloGene: 31382; GeneCards: HEXIM1; OMA:HEXIM1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 45,148,475 bp[1] End 45,152,099 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 103,007,057 bp[2] End 103,010,551 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte middle temporal gyrus gingival epithelium germinal epithelium kidney tubule glomerulus Brodmann area 23 placenta metanephric glomerulus amniotic fluid Top expressed in gastrula median eminence adrenal gland transitional epithelium of urinary bladder lateral geniculate nucleus ascending aorta granulocyte medial geniculate nucleus ciliary body central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding snRNA binding 7SK snRNA binding cyclin-dependent protein serine/threonine kinase inhibitor activity Cellular component nucleoplasm cytoplasm nucleus Biological process positive regulation of signal transduction by p53 class mediator heart development regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II activation of innate immune response immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10614 192231 Ensembl ENSG00000186834 ENSMUSG00000048878 UniProt O94992 Q8R409 RefSeq (mRNA) NM_006460 NM_138753 RefSeq (protein) NP_006451 NP_620092 Location (UCSC) Chr 17: 45.15 – 45.15 Mb Chr 11: 103.01 – 103.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HEXIM1 has been shown to interact with Cyclin T1^[6] and Cdk9^[8]