DCP1A

mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene.^[5]

DCP1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WX3, 4B6H
Identifiers
Aliases	DCP1A, HSA275986, Nbla00360, SMAD4IP1, SMIF, decapping mRNA 1A
External IDs	OMIM: 607010; MGI: 1923151; HomoloGene: 10178; GeneCards: DCP1A; OMA:DCP1A - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 53,283,429 bp[1] End 53,347,586 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 18.75 cM Start 30,201,492 bp[2] End 30,249,020 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte cartilage tissue testicle Achilles tendon gonad sural nerve tibialis anterior muscle buccal mucosa cell islet of Langerhans Top expressed in secondary oocyte zygote primary oocyte medullary collecting duct tail of embryo saccule otic vesicle genital tubercle otic placode cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity enzyme activator activity protein binding mRNA binding hydrolase activity identical protein binding kinesin binding Cellular component cytoplasm cytosol membrane nucleus P-body cytoplasmic ribonucleoprotein granule Biological process positive regulation of catalytic activity deadenylation-independent decapping of nuclear-transcribed mRNA protein localization to cytoplasmic stress granule regulation of mRNA stability deadenylation-dependent decapping of nuclear-transcribed mRNA exonucleolytic catabolism of deadenylated mRNA nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55802 75901 Ensembl ENSG00000272886 ENSMUSG00000021962 UniProt Q9NPI6 Q91YD3 RefSeq (mRNA) NM_018403 NM_001290204 NM_001290205 NM_001290206 NM_001290207 NM_133761 RefSeq (protein) NP_001277133 NP_001277134 NP_001277135 NP_001277136 NP_060873 NP_598522 Location (UCSC) Chr 3: 53.28 – 53.35 Mb Chr 14: 30.2 – 30.25 Mb PubMed search [3] [4]
Wikidata
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Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.^[5]

Interactions

DCP1A has been shown to interact with DCP2^[6] and UPF1.^[6] It has also been shown to colocalize with GW182, and other markers of P-body.^[7] Human DCP1A is heterotrimeric,^[8] and makes contacts with the scaffold EDC3/4.^[9] The Arabidopsis thaliana homolog interacts with the plant specific type XI myosin motor protein.^[10]