DCTN2

Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene.^[4][5]

DCTN2
Identifiers
Aliases	DCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50, dynactin subunit 2
External IDs	OMIM: 607376; MGI: 107733; HomoloGene: 4667; GeneCards: DCTN2; OMA:DCTN2 - orthologs
Gene location (Mouse) Chr. Chromosome 10 (mouse)[1] Band 10 D3|10 74.5 cM Start 127,102,237 bp[1] End 127,117,819 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in spermatocyte spermatid seminiferous tubule dentate gyrus of hippocampal formation granule cell superior frontal gyrus lip ventricular zone primary visual cortex cerebellar cortex granulocyte BioGPS More reference expression data
Gene ontology Molecular function spectrin binding protein binding cytoskeletal motor activity identical protein binding protein kinase binding host cell surface receptor binding Cellular component vesicle centrosome membrane dynactin complex growth cone microtubule organizing center dynein complex microtubule extracellular exosome cytoskeleton kinetochore cytoplasm cytosol Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle organization endoplasmic reticulum to Golgi vesicle-mediated transport G2/M transition of mitotic cell cycle melanosome transport microtubule-based process protein localization to centrosome cell population proliferation ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10540 69654 Ensembl ENSG00000175203 ENSMUSG00000025410 UniProt Q13561 Q99KJ8 RefSeq (mRNA) NM_001261412 NM_001261413 NM_006400 NM_001190453 NM_001190454 NM_027151 RefSeq (protein) NP_001248341 NP_001248342 NP_006391 NP_001334994 NP_001334995 NP_001334996 NP_001334997 NP_001177382 NP_001177383 NP_081427 Location (UCSC) n/a Chr 10: 127.1 – 127.12 Mb PubMed search [2] [3]
Wikidata
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Function

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD).^[6] The subunit is commonly referred to as p50 or dynamitin.^[4] Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in four copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that bind to two copies of p150-glued (DCTN1) and two copies of p24 (DCTN3) to form the dynactin shoulder domain.^[6]

Interactions

DCTN2 has been shown to interact with MARCKSL1.^[7]