MARCKSL1

MARCKS-related protein is a protein that in humans is encoded by the MARCKSL1 gene.^[5][6]

MARCKSL1
Identifiers
Aliases	MARCKSL1, F52, MACMARCKS, MLP, MLP1, MRP, MARCKS-like 1, MARCKS like 1
External IDs	OMIM: 602940; MGI: 97143; HomoloGene: 40748; GeneCards: MARCKSL1; OMA:MARCKSL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.1 Start 32,333,839 bp[1] End 32,336,233 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 63.26 cM Start 129,407,374 bp[2] End 129,409,778 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve ganglionic eminence spinal cord C1 segment superior vestibular nucleus middle frontal gyrus subthalamic nucleus Pons ventricular zone ventral tegmental area Top expressed in neural tube maxillary prominence medial ganglionic eminence mandibular prominence somite abdominal wall ventricular zone primitive streak transitional epithelium of urinary bladder vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding calmodulin binding Cellular component cytoplasm plasma membrane extracellular exosome membrane cytoskeleton Biological process positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65108 17357 Ensembl ENSG00000175130 ENSMUSG00000047945 UniProt P49006 P28667 RefSeq (mRNA) NM_023009 NM_010807 RefSeq (protein) NP_075385 NP_034937 Location (UCSC) Chr 1: 32.33 – 32.34 Mb Chr 4: 129.41 – 129.41 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. MARCKS plays a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junctions. Alternative splicing results in multiple transcript variants.^[6]

Interactions

MARCKSL1 has been shown to interact with DCTN2^[7] and JNK.^[8]