DDX17

Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene.^[5][6]

DDX17
Identifiers
Aliases	DDX17, P72, RH70, DEAD-box helicase 17
External IDs	OMIM: 608469; MGI: 1914290; HomoloGene: 101101; GeneCards: DDX17; OMA:DDX17 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,483,438 bp[1] End 38,507,660 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,411,937 bp[2] End 79,430,942 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia middle temporal gyrus Brodmann area 23 endothelial cell germinal epithelium visceral pleura parietal pleura Epithelium of choroid plexus right uterine tube corpus callosum Top expressed in medullary collecting duct renal corpuscle condyle fossa Rostral migratory stream Gonadal ridge vas deferens ciliary body iris primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding RNA helicase activity protein binding ATP binding helicase activity transcription coactivator activity hydrolase activity nucleic acid binding ATP-dependent activity, acting on RNA RNA binding Cellular component membrane nucleus nuclear speck cytosol nucleoplasm nucleolus cytoplasm Biological process RNA processing RNA secondary structure unwinding regulation of transcription, DNA-templated transcription, DNA-templated regulation of skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II regulation of alternative mRNA splicing, via spliceosome alternative mRNA splicing, via spliceosome regulation of transcription by RNA polymerase II miRNA metabolic process intracellular estrogen receptor signaling pathway androgen receptor signaling pathway epithelial to mesenchymal transition myoblast differentiation immune system process rRNA processing mRNA processing RNA splicing gene silencing defense response to virus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10521 67040 Ensembl ENSG00000100201 ENSMUSG00000055065 UniProt Q92841 Q501J6 RefSeq (mRNA) NM_030881 NM_001098504 NM_001098505 NM_006386 NM_001040187 NM_152806 NM_199079 NM_199080 RefSeq (protein) NP_001091974 NP_006377 NP_001035277 NP_690019 NP_951061 NP_951062 Location (UCSC) Chr 22: 38.48 – 38.51 Mb Chr 15: 79.41 – 79.43 Mb PubMed search [3] [4]
Wikidata
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Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.^[6]

Interactions

DDX17 has been shown to interact with:

• DDX5 (p68),^[7]
• DHX9 (RNA Helicase A),^[8]
• HDAC1,^[9]