DDX5

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.^[5]

DDX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FE2, 4A4D
Identifiers
Aliases	DDX5, G17P1, HLR1, HUMP68, p68, DEAD-box helicase 5
External IDs	OMIM: 180630; MGI: 105037; HomoloGene: 6797; GeneCards: DDX5; OMA:DDX5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.3 Start 64,498,254 bp[1] End 64,508,199 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 70.01 cM Start 106,671,181 bp[2] End 106,680,011 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon bone marrow cells granulocyte anterior pituitary right adrenal cortex smooth muscle tissue epithelium of colon gonad monocyte right lobe of thyroid gland Top expressed in lobe of cerebellum cerebellar vermis neural layer of retina olfactory tubercle granulocyte habenula median eminence pineal gland arcuate nucleus lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding helicase activity calcium-dependent protein binding calmodulin binding protein binding androgen receptor binding nucleic acid binding enzyme binding pre-mRNA binding hydrolase activity ATP binding RNA helicase activity RNA binding mRNA 3'-UTR binding ribonucleoprotein complex binding promoter-specific chromatin binding MH2 domain binding SMAD binding R-SMAD binding primary miRNA binding transcription coregulator activity Cellular component catalytic step 2 spliceosome membrane nucleolus spliceosomal complex extracellular exosome nucleus extracellular matrix nucleoplasm SMAD protein complex cytoplasm ribonucleoprotein complex Biological process regulation of skeletal muscle cell differentiation regulation of transcription, DNA-templated rhythmic process regulation of viral genome replication mRNA processing mRNA transcription negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell growth regulation of osteoblast differentiation RNA secondary structure unwinding intrinsic apoptotic signaling pathway by p53 class mediator RNA splicing regulation of androgen receptor signaling pathway positive regulation of DNA damage response, signal transduction by p53 class mediator mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process alternative mRNA splicing, via spliceosome regulation of transcription by RNA polymerase II intracellular estrogen receptor signaling pathway androgen receptor signaling pathway epithelial to mesenchymal transition myoblast differentiation pri-miRNA transcription by RNA polymerase II BMP signaling pathway regulation of pri-miRNA transcription by RNA polymerase II positive regulation of production of miRNAs involved in gene silencing by miRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1655 13207 Ensembl ENSG00000108654 ENSMUSG00000020719 UniProt P17844 Q61656 RefSeq (mRNA) NM_004396 NM_001320595 NM_001320596 NM_001320597 NM_007840 NM_001355676 NM_001355677 RefSeq (protein) NP_001307524 NP_001307525 NP_001307526 NP_004387 n/a Location (UCSC) Chr 17: 64.5 – 64.51 Mb Chr 11: 106.67 – 106.68 Mb PubMed search [3] [4]
Wikidata
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Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,^[6] and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.^[5]

Interactions

DDX5 has been shown to interact with:

• AKAP8,^[7]
• DDX17 (p72),^[8]
• DHX9 (RNA helicase A),^[9]
• Estrogen receptor alpha,^[10]
• Fibrillarin,^[11]
• HDAC1,^[12]
• p53,^[13]
• CTCF.^[14]