DLG2

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.^[5][6]

DLG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BYG, 2HE2
Identifiers
Aliases	DLG2, PPP1R58, PSD-93, PSD93, chapsyn-110, discs large homolog 2, discs large MAGUK scaffold protein 2
External IDs	OMIM: 603583; MGI: 1344351; HomoloGene: 1046; GeneCards: DLG2; OMA:DLG2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.1 Start 83,455,012 bp[1] End 85,627,922 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 E1|7 51.07 cM Start 90,476,672 bp[2] End 92,449,247 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell corpus callosum inferior ganglion of vagus nerve prefrontal cortex right frontal lobe entorhinal cortex middle temporal gyrus nucleus accumbens hippocampus proper Brodmann area 23 Top expressed in superior frontal gyrus lateral septal nucleus lobe of cerebellum piriform cortex dentate gyrus of hippocampal formation granule cell olfactory tubercle cerebellar vermis anterior amygdaloid area primary motor cortex neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanylate kinase activity kinase binding protein binding ionotropic glutamate receptor binding structural constituent of postsynaptic density Cellular component postsynaptic membrane cell projection membrane postsynaptic density voltage-gated potassium channel complex plasma membrane synapse axon cell junction basolateral plasma membrane ionotropic glutamate receptor complex juxtaparanode region of axon cytosol neuromuscular junction neuron projection postsynaptic density membrane glutamatergic synapse axon cytoplasm Biological process chemical synaptic transmission receptor localization to synapse negative regulation of phosphatase activity receptor clustering nervous system development establishment or maintenance of epithelial cell apical/basal polarity sensory perception of pain GDP metabolic process GMP metabolic process MAPK cascade cellular response to potassium ion cell-cell adhesion maintenance of postsynaptic density structure anterograde axonal protein transport retrograde axonal protein transport neurotransmitter receptor localization to postsynaptic specialization membrane regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1740 23859 Ensembl ENSG00000150672 ENSMUSG00000052572 UniProt Q15700 Q91XM9 RefSeq (mRNA) NM_001142699 NM_001142700 NM_001142702 NM_001206769 NM_001300983 NM_001364 NM_001351274 NM_001351275 NM_001351276 NM_001377966 NM_001377967 NM_001377968 NM_001377970 NM_001377971 NM_001377972 NM_001377973 NM_001377974 NM_001377975 NM_001377976 NM_001377977 NM_001377978 NM_001377979 NM_001377980 NM_001377981 NM_001377982 NM_001377983 NM_175892 NM_001243046 NM_001243047 NM_011807 RefSeq (protein) NP_001136171 NP_001136172 NP_001136174 NP_001193698 NP_001287912 NP_001355 NP_001338203 NP_001338204 NP_001338205 NP_001364895 NP_001364896 NP_001364897 NP_001364899 NP_001364900 NP_001364901 NP_001364902 NP_001364903 NP_001364904 NP_001364905 NP_001364906 NP_001364907 NP_001364908 NP_001364909 NP_001364910 NP_001364911 NP_001364912 NP_001229975 NP_001229976 NP_035937 Location (UCSC) Chr 11: 83.46 – 85.63 Mb Chr 7: 90.48 – 92.45 Mb PubMed search [3] [4]
Wikidata
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Function

Chapsyn-110/PSD-93 a member of the membrane-associated guanylate kinase (MAGUK) family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.^[7]

Interactions

DLG2 has been shown to interact with GRIN2B,^[8][9] KCNJ12.^[10]