DLG5

Disks large homolog 5 is a protein that in humans is encoded by the DLG5 gene.^[5][6]

DLG5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UIT
Identifiers
Aliases	DLG5, LP-DLG, P-PDLG, discs large homolog 5, discs large MAGUK scaffold protein 5
External IDs	OMIM: 604090; MGI: 1918478; HomoloGene: 3486; GeneCards: DLG5; OMA:DLG5 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.3 Start 77,790,791 bp[1] End 77,926,755 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 24,184,021 bp[2] End 24,295,988 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone left adrenal cortex right adrenal cortex ganglionic eminence placenta stromal cell of endometrium pituitary gland skin of abdomen prostate skin of leg Top expressed in genital tubercle ventricular zone Gonadal ridge external carotid artery gastrula cumulus cell mandibular prominence stroma of bone marrow tail of embryo human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding cytoskeletal protein binding protein binding signaling receptor complex adaptor activity Cellular component membrane plasma membrane cell junction postsynaptic density ciliary basal body cytoplasm cytoskeleton cell projection synapse postsynaptic membrane Biological process regulation of apoptotic process polarized epithelial cell differentiation intracellular signal transduction apical protein localization establishment or maintenance of epithelial cell apical/basal polarity protein localization to adherens junction metanephric collecting duct development epithelial tube branching involved in lung morphogenesis zonula adherens assembly midbrain development signal transduction negative regulation of cell population proliferation epithelial to mesenchymal transition maintenance of cell polarity negative regulation of cell migration negative regulation of hippo signaling positive regulation of hippo signaling negative regulation of T cell proliferation positive regulation of smoothened signaling pathway positive regulation of synapse assembly positive regulation of dendritic spine development cell-cell adhesion protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9231 71228 Ensembl ENSG00000151208 ENSG00000274429 ENSMUSG00000021782 UniProt Q8TDM6 E9Q9R9 RefSeq (mRNA) NM_004747 NM_001163513 NM_027726 RefSeq (protein) NP_004738 NP_001156985 NP_082002 Location (UCSC) Chr 10: 77.79 – 77.93 Mb Chr 14: 24.18 – 24.3 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.^[6]

Interactions

DLG5 has been shown to interact with SORBS3.^[7]