SORBS3

Vinexin is a protein that in humans is encoded by the SORBS3 gene.^[5][6][7]

SORBS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CT3, 2DLM, 2NWM, 2YUP
Identifiers
Aliases	SORBS3, SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
External IDs	OMIM: 610795; MGI: 700013; HomoloGene: 4218; GeneCards: SORBS3; OMA:SORBS3 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,544,986 bp[1] End 22,575,788 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D2|14 36.27 cM Start 70,417,917 bp[2] End 70,449,438 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis right coronary artery popliteal artery tibial arteries tibial nerve gastric mucosa left coronary artery canal of the cervix ascending aorta Top expressed in external carotid artery muscle of thigh internal carotid artery genital tubercle retinal pigment epithelium vestibular membrane of cochlear duct ankle right lung right lung lobe choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vinculin binding transcription factor binding structural constituent of cytoskeleton protein binding Cellular component cytoplasm cytosol cell junction cytoskeleton nucleus focal adhesion Biological process cell-substrate adhesion cell adhesion muscle contraction negative regulation of transcription by RNA polymerase II positive regulation of stress fiber assembly positive regulation of cytoskeleton organization positive regulation of MAPK cascade actin filament organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10174 20410 Ensembl ENSG00000120896 ENSMUSG00000022091 UniProt O60504 Q9R1Z8 RefSeq (mRNA) NM_001018003 NM_005775 NM_001271407 NM_001271408 NM_001271409 NM_011366 RefSeq (protein) NP_001018003 NP_005766 NP_001258336 NP_001258337 NP_001258338 NP_035496 Location (UCSC) Chr 8: 22.54 – 22.58 Mb Chr 14: 70.42 – 70.45 Mb PubMed search [3] [4]
Wikidata
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Interactions

SORBS3 has been shown to interact with DLG5^[8] and MAPK1.^[9]