DLGAP1

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post-synaptic density.^[5]

DLGAP1
Identifiers
Aliases	DLGAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP, discs large homolog associated protein 1, DLG associated protein 1
External IDs	OMIM: 605445; MGI: 1346065; HomoloGene: 31258; GeneCards: DLGAP1; OMA:DLGAP1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.31 Start 3,496,032 bp[1] End 4,455,307 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 E1.3|17 40.85 cM Start 70,276,068 bp[2] End 71,128,408 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell primary visual cortex prefrontal cortex Pons dorsolateral prefrontal cortex Brodmann area 9 Parietal Lobe superior frontal gyrus right frontal lobe Top expressed in piriform cortex subiculum primary motor cortex cingulate gyrus subdivision of hippocampus Region I of hippocampus proper lateral septal nucleus cerebellar vermis lobe of cerebellum anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein domain specific binding protein-containing complex binding Cellular component cell junction postsynaptic membrane postsynaptic density membrane plasma membrane synapse cellular component Biological process signaling chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9229 224997 Ensembl ENSG00000170579 ENSMUSG00000003279 UniProt O14490 Q9D415 RefSeq (mRNA) NM_001003809 NM_001242761 NM_001242762 NM_001242763 NM_001242764 NM_001242765 NM_001242766 NM_001308390 NM_004746 NM_001128180 NM_001128181 NM_027712 NM_177639 NM_001347411 NM_001347412 NM_001347413 NM_001347414 NM_001360665 RefSeq (protein) NP_001003809 NP_001229690 NP_001229691 NP_001229692 NP_001229693 NP_001229694 NP_001229695 NP_001295319 NP_004737 NP_001121652 NP_001121653 NP_001334340 NP_001334341 NP_001334342 NP_001334343 NP_081988 NP_808307 NP_001347594 Location (UCSC) Chr 18: 3.5 – 4.46 Mb Chr 17: 70.28 – 71.13 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK2 and PSD-95 proteins, facilitating the assembly of the post-synaptic density of neurons.^[6] Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.

Interactions

DLGAP1 has been shown to interact with:

• DLG1^{[7][8][9][10]}
• DLG4^{[7][8][9][10][11][12]}
• DYNLL1^[11]
• DYNLL2^[11]
• SHANK2^[11][12]

The interaction with PSD95 and S-SCAM is mediated by the GUK domain^[13] and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.