DYNLL2

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.^[5][6]

DYNLL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XQQ, 3P8M, 4D07, 1PWJ
Identifiers
Aliases	DYNLL2, DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDs	OMIM: 608942; MGI: 1915347; HomoloGene: 115597; GeneCards: DYNLL2; OMA:DYNLL2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 58,083,419 bp[1] End 58,095,542 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 87,870,351 bp[2] End 87,878,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus myocardium of left ventricle sperm cardiac muscle tissue of right atrium skin of arm mucosa of ileum Pons superior vestibular nucleus pars compacta ventral tegmental area Top expressed in motor neuron mammillary body lateral hypothalamus lateral geniculate nucleus seminiferous tubule ventromedial nucleus medial vestibular nucleus dorsomedial hypothalamic nucleus cingulate gyrus lateral septal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity protein binding plus-end-directed microtubule motor activity dynein intermediate chain binding dynein light intermediate chain binding cytoskeletal protein binding protein homodimerization activity protein heterodimerization activity scaffold protein binding Cellular component cytoplasm cytosol nucleus membrane ciliary tip centrosome microtubule plasma membrane microtubule associated complex dynein complex cytoskeleton mitochondrion cilium myosin V complex cytoplasmic dynein complex myosin complex postsynaptic density postsynapse glutamatergic synapse Biological process microtubule-based process antigen processing and presentation of exogenous peptide antigen via MHC class II endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway macroautophagy intraciliary transport involved in cilium assembly transport along microtubule cilium assembly sister chromatid cohesion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140735 68097 Ensembl ENSG00000264364 ENSMUSG00000020483 UniProt Q96FJ2 Q9D0M5 RefSeq (mRNA) NM_080677 NM_001168471 NM_001168472 NM_026556 RefSeq (protein) NP_542408 NP_001161943 NP_001161944 NP_080832 Location (UCSC) Chr 17: 58.08 – 58.1 Mb Chr 11: 87.87 – 87.88 Mb PubMed search [3] [4]
Wikidata
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Interactions

DYNLL2 has been shown to interact with DLG4,^[7] C12orf40,^[8] DLGAP1,^[7] MYO5A^[7][9] and BMF.^[9][10]