DMAP1

DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.^[5][6][7]

DMAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HM5, 4IEJ
Identifiers
Aliases	DMAP1, DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4, DNA methyltransferase 1 associated protein 1
External IDs	OMIM: 605077; MGI: 1913483; HomoloGene: 41311; GeneCards: DMAP1; OMA:DMAP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 44,213,455 bp[1] End 44,220,681 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 117,531,878 bp[2] End 117,539,470 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex right uterine tube granulocyte right hemisphere of cerebellum Brodmann area 9 right frontal lobe anterior pituitary right lobe of thyroid gland mucosa of transverse colon Top expressed in superior surface of tongue gallbladder extensor digitorum longus muscle spermatocyte plantaris muscle cardiac muscle tissue of left ventricle primary oocyte seminiferous tubule corneal stroma spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding Cellular component replication fork cytoplasm NuA4 histone acetyltransferase complex nucleus nucleoplasm cytosol Biological process chromatin remodeling regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated DNA methylation regulation of growth response to ethanol DNA repair negative regulation of transcription, DNA-templated histone H4 acetylation histone H2A acetylation chromatin organization positive regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55929 66233 Ensembl ENSG00000178028 ENSMUSG00000009640 UniProt Q9NPF5 Q5TG37 Q9JI44 RefSeq (mRNA) NM_001034023 NM_001034024 NM_019100 NM_023178 RefSeq (protein) NP_001029195 NP_001029196 NP_061973 NP_075667 Location (UCSC) Chr 1: 44.21 – 44.22 Mb Chr 4: 117.53 – 117.54 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.^[7]

Interactions

DMAP1 has been shown to interact with:

• C19orf2,^[8]
• DNMT1,^[9]
• ING1,^[10] and
• RGS6^[11]