ING1

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.^[5][6][7]

ING1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QIC
Identifiers
Aliases	ING1, p24ING1c, p33, p33p33ING1b, p47, p47ING1a, inhibitor of growth family member 1
External IDs	OMIM: 601566; MGI: 1349481; HomoloGene: 40119; GeneCards: ING1; OMA:ING1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 110,712,736 bp[1] End 110,723,339 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A1.1 Start 11,605,571 bp[2] End 11,613,251 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ganglionic eminence ventricular zone gonad left testis right testis monocyte endothelial cell blood decidua Top expressed in primitive streak genital tubercle Rostral migratory stream tail of embryo secondary oocyte ureter vas deferens medullary collecting duct abdominal wall primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylated histone binding protein binding metal ion binding Cellular component nucleus Biological process regulation of cell death cell cycle negative regulation of cell growth negative regulation of cell population proliferation positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3621 26356 Ensembl ENSG00000153487 ENSMUSG00000045969 UniProt Q9UK53 Q9QXV3 RefSeq (mRNA) NM_198219 NM_001267728 NM_005537 NM_198217 NM_198218 NM_011919 NM_001302451 NM_001302457 NM_001302458 NM_001302459 NM_001302460 RefSeq (protein) NP_001254657 NP_005528 NP_937860 NP_937861 NP_937862 NP_001289380 NP_001289386 NP_001289387 NP_001289388 NP_001289389 NP_036049 Location (UCSC) Chr 13: 110.71 – 110.72 Mb Chr 8: 11.61 – 11.61 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

One of the isoforms of ING1 (p33(ING1) is involved in the modulation of DNA repair.^[8] It appears that p33(ING1) cooperates with p53 in nucleotide excision repair.^[8] Also, proliferating cell nuclear antigen (PCNA) interacts with p33(ING1b) in the elimination of UV-damaged cells through the induction of programmed cell death (apoptosis).^[9]

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

• CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
• COL4A2: A2 Subunit of type IV collagen
• RAB20: Potential regulator of Connexin 43 trafficking.
• CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

ING1 has been shown to interact with:

• CREB binding protein,^[10]
• DMAP1,^[11]
• HDAC1,^[10][12]
• P53,^[13][14]
• PCNA,^[15]
• SAP30,^[12]
• SIN3A,^[12]
• SMARCA4,^[12] and
• SMARCC1.^[12]