DNAJA1

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.^[5][6][7]

DNAJA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LO1, 2M6Y
Identifiers
Aliases	DNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2, HSJ-2, DnaJ heat shock protein family (Hsp40) member A1
External IDs	OMIM: 602837; MGI: 1270129; HomoloGene: 55588; GeneCards: DNAJA1; OMA:DNAJA1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.1 Start 33,025,273 bp[1] End 33,039,907 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 40,722,150 bp[2] End 40,737,149 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte bronchial epithelial cell ganglionic eminence amniotic fluid mucosa of paranasal sinus secondary oocyte mucosa of sigmoid colon ventricular zone beta cell stromal cell of endometrium Top expressed in genital tubercle tail of embryo morula morula facial motor nucleus right kidney ganglionic eminence blastocyst dentate gyrus of hippocampal formation granule cell anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding heat shock protein binding unfolded protein binding C3HC4-type RING finger domain binding metal ion binding low-density lipoprotein particle receptor binding Hsp70 protein binding protein binding G protein-coupled receptor binding ATP binding ubiquitin protein ligase binding Tat protein binding ATPase activator activity Cellular component cytoplasm membrane intracellular membrane-bounded organelle ubiquitin ligase complex mitochondrion cytoplasmic side of endoplasmic reticulum membrane endoplasmic reticulum perinuclear region of cytoplasm extracellular exosome nucleus microtubule cytoskeleton cytosol Biological process flagellated sperm motility androgen receptor signaling pathway regulation of protein transport negative regulation of apoptotic process response to heat toxin transport negative regulation of protein ubiquitination response to unfolded protein protein folding spermatogenesis positive regulation of apoptotic process protein localization to mitochondrion negative regulation of JUN kinase activity negative regulation of establishment of protein localization to mitochondrion negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of ATP-dependent activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3301 15502 Ensembl ENSG00000086061 ENSMUSG00000028410 UniProt P31689 P63037 RefSeq (mRNA) NM_001539 NM_001314039 NM_001164671 NM_001164672 NM_008298 RefSeq (protein) NP_001300968 NP_001530 NP_001158143 NP_001158144 NP_032324 Location (UCSC) Chr 9: 33.03 – 33.04 Mb Chr 4: 40.72 – 40.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

DNAJA1 has been shown to interact with PTTG1.^[8]